منابع مشابه
Beta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells
Background: The canonical Wnt signal transduction (or the Wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. Beta-catenin is the central component of this signaling pathway. The activation of Wnt/β-catenin signaling results in the cytoplasmic and nuclear accumulation of β-catenin. In the nucleus, β-catenin interacts with the TCF/LEF transcription fa...
متن کاملbeta-catenin forms protein aggregation at high concentrations in hek293tcells
background: the canonical wnt signal transduction (or the wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. beta-catenin is the central component of this signaling pathway. the activation of wnt/β-catenin signaling results in the cytoplasmic and nuclear accumulation of β-catenin. in the nucleus, β-catenin interacts with the tcf/lef transcription fa...
متن کاملComparative In silico Study of Sex-Determining Region Y (SRY) Protein Sequences Involved in Sex-Determining
Background: The SRY gene (SRY) provides instructions for making a transcription factor called the sex-determining region Y protein. The sex-determining region Y protein causes a fetus to develop as a male. In this study, SRY of 15 spices included of human, chimpanzee, dog, pig, rat, cattle, buffalo, goat, sheep, horse, zebra, frog, urial, dolphin and killer whale were used for determine of bioi...
متن کاملProtein aggregation
As a rule amyloid fibrils appear as unbranched, long rodor ribbon-like structures with the typical diameter of about 10 nm and the length reaching up to 1μm and more. Amyloid fibrils are exceptionally stable against chemical denaturants or temperature. Experiments show that they can withstand up to 8M urea or the temperatures as high as 100 °C (prion fibrils). From a macroscopic viewpoint, form...
متن کاملHydrophobic collapse in (in silico) protein folding
A model of hydrophobic collapse, which is treated as the driving force for protein folding, is presented. This model is the superposition of three models commonly used in protein structure prediction: (1) 'oil-drop' model introduced by Kauzmann, (2) a lattice model introduced to decrease the number of degrees of freedom for structural changes and (3) a model of the formation of hydrophobic core...
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ژورنال
عنوان ژورنال: Trends in Biotechnology
سال: 2007
ISSN: 0167-7799
DOI: 10.1016/j.tibtech.2007.03.011